Cascading flow and multi-organ device, for cells-in-system approaches.
An in vitro cell culture tool that consists of wells linked together through microfluidic channels and a syphon-drive system that controls flow through and between wells. The system allows for a "tempered" flow of chemical concentrations through wells either of a single lineage or between multiple lineages. The device advances nutrient transport for ‘cells in system’ approaches, and was designed to retain traditional culture configurations while advancing fluid distributions with grafted flow paths. This affords users the option to evaluate networked –cell, -tissue, and -environment relationships.
SciKon Innovation is creating human organ systems for the benchtop.
We engage in scientific engineering and construction, with biological relevance. SciKon approaches biotools by embracing a deep understanding of engineering and a love for biology of the human body. Our mission is to produce improved bio-tools for biomedical and pharmaceutical applications by exploiting engineering principles to produce human-relevant cell ecosystems. Specifically, we engineer tools that integrate human cells, tissues, and organs in controlled and modifiable environments. These cell culture systems lead to improved predictive models of the body’s response to toxins, drugs, and medications.
Save Your Cells! Thawing media for cryopreserved cells.
Improve your organization’s cellular systems. KryoThaw, a unique thawing media for cryopreserved cells, can increase cell viability, quality of cell yield, and cell plateability. KryoThaw improves upon the three primary modes of cryopreservation cell decay: physical cell rupture, cell necrosis, and apoptosis. This ready-to-use product simply requires a 1-step centrifugation process. Versions have been optimized for hepatocytes, intestinal cells, and progenitors.
Scientific Construction. Merging engineering and environments in support of biological relevance.
SciKon’s industrial and academic experiences are focused on bioengineered 2D and 3D environment-cell interactions. Our involvement includes human tissue procurement, primary cell development, bioreactor culture pharmaceutical trials, cryopreservation and cell thaw technology, and native “single organ” and “multi organ” in vitro co-culture systems. We amend mother natures’ native microenvironment design for the in vitro maintenance of cell health.
Human Hepatitis B virus models using Pekin Ducks.
Due to the narrow host range of hepatitis B virus (HBV) that infects humans, the closely related duck HBV (DHBV) provides a useful model in the hepadnavirus life cycle, virus-host interactions, and antiviral strategies.

Biotools to re-create the body’s response to disease.

Recent SciFlow 1000 News
  • Mass produced (IM); Jan 2017.
  • International Distribution; Jan 2017.
  • Human Disease Modeling; 2016.
  • R&D Grants Program;  ongoing.
Device Design Prototype
Your Purchase Avenues
  • E-commerce
  • Purchase Order
  • Distributor
  • Call us
Positioned for the Future
  • Benchtop human systems
  • Metabolism & Bioactivation
  • Real-time drug exposures
  • Toxicity in pre-clinical medicine
  • Accelerate predictive models
Microfluidics & Grants
  • Multi-organ tools & bioapplications
  • Real-time drug exposures
  • We submit SBIR grant applications
  • We subcontract on grants
Veteran Owned/Registered
CRO Services

Lab Service Offerings

SciKon is committed to delivering in vitro drug toxicity services in support of our clients’ drug development needs.  Many of our development activities are focused in early drug discovery, lead selection/optimization, metabolism, bioactivation, and systems physiology.  By leveraging advanced 2D & 3D plate-based benchtop techniques, SciKon can rapidly perform key assays (real-time and/or end-study) that allow you to identify potential issues with compounds that are being developed.

Two intrinsic examples: 1) SciKon’s resources include automated x,y,z high-throughput (HTP) imagers and readers for 3D culture evaluations with concurrent fluid flow analysis.  2) SciKon’s exclusive microfluidic SciFlow technology allows researchers to identify the difference between compound-related toxicity, metabolite-related toxicity, and concurrently delivers key cell bioactivation data in both HTP and data-centric outcomes (a montage assembly of data).

Metabolism Toxicity / Cytotoxicity

  • Exposure Time Course (multiple days)
  • Dose Response Curves (low -> high)
  • CellTiter Glo ATP Deletion Assay
  • LDH, MTT, Live/Dead Assays

Hepatotoxicty / Cell Functions

  • Hepatocyte Cell Viability / Urea
  • Steatosis and Phospholipidosis
  • CYP / Enzyme Induction

Mitochondrial Toxicity

  • Mitochondrial Membrane Potential Assay
  • Metabolism (cell energy flux assay)
  • Hepatocyte (RST/OCR) Assay

 

In Vitro "versus" In Vivo
  • SciKon’s in vitro models are formulated to better recapitulate in vivo responses
  • Our systems use fluid flow and non-linear toxicant exposure to simulate realistic pharmacokinetics
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